Immune Deficiency in Children
A type of white blood cell—the T-cell—is a critical component of immunity
in both children and adults.
To defend against disease, T-cells must move efficiently through the body, on a
search and destroy mission for bacteria, viruses, cancer cells, and other invaders.
When T-cells fail to move and function adequately, pediatric patients face
an increased risk of infection, cancer, and autoimmune diseases like lupus erythematosus.
To understand the T-cell, its movement, and its activation, S. Celeste
Morley, MD, PhD studies the effect of a protein, called L-plastin,
on T-cell function.
Recently, Dr. Morley was named a Faculty Scholar of the Children’s Discovery
Institute. Her grant from the Institute will help support research that,
in the short-term, seeks to explain how L-plastin deficiency might adversely affect
the immune response to infection in children. In the long-term, Dr. Morley’s
research may result in new ways to manage children with immunodeficiencies.
Click here to learn about a recent publication on L-plastin by Dr. Morley and hercolleagues.
Click here to read more on our website about Dr. Morley's research.