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Research Highlights
Seeking a Fighting Chance for Cystic Fibrosis Patients

When you have two great passions — children and science — going to medical school and becoming a pediatrician seem like obvious choices. But, choosing a pediatric specialty proved more challenging for Jessica Pittman, MD, MPH, pediatrics, until she met Dylan. ...Learn More

New Research on Pediatric Brain Tumors Underway

According to Dr. Rubin, MD, PhD, pediatrics, despite decades of research, we still have little understanding of the fundamental mechanisms that drive the genesis of pediatric brain tumors and the requirements for effective treatment. Now, the discovery of a key player in making brain tumors resistant to treatment by Washington University School of Medicine’s Albert Kim, MD, PhD, neurosurgery, will inform a CDI study that brings Dr. Kim together with Dr. Rubin, developmental biologist Kristen Kroll, PhD, and Hiroko Yano, PhD, an expert in neuro-epigenetics, as co-principal investigators to crack the code of what happens during brain stem cell differentiation that sets a child on the path to developing this malignant brain tumor. ...Learn More

Moving Toward Personalized Medicine

Learn how a little boy helped researchers gain a greater understanding of our immune system....Learn More

Healing a Broken Heart

Can we put immune cells to work to reverse pediatric cardiomyopathy? One CDI researcher intends to find out....Learn More

In Defense of the Peanut

A New CDI study seeks to uncover the early environmental exposures that put children at risk for food allergies....Learn More

News & Events
Development of Gut Microbes and Gut Immunity Linked CDI-funded research studying twins from birth to age 2 has shown that the gut’s immune system develops in sync with the gut’s tens of trillions of microbes.... CDI More Info
Antibiotic Resistance Hot Spots Identified CDI investigator Gautam Dantas, PhD, led a study that surveyed ecosystems of bacteria and their capacity to resist antibiotics in low resource communities and identified areas ripe for bacteria to shuffle and share their resistance genes.... CDI More Info
The CDI Welcomes New Executive Director Gary A. Silverman, MD, PhD, a national leader in newborn medicine, has been named the Harriet B. Spoehrer Professor and head of the Department of Pediatrics at Washington University School of Medicine in St. Louis. With the new appointment, effective in April, Dr. Silverman will become pediatrician-in-chief at St. Louis Children’s Hospital and executive director of the Children’s Discovery Institute.... CDI More Info
CDI Researchers Now Part of Pediatric Neuro-Oncology Consortium When the Washington University School of Medicine joined the Pacific Pediatric Neuro-Oncology Consortium, it brought with it three CDI-funded physician-scientists who now have access to the most cutting-edge brain tumor therapies for the children of St. Louis and surrounding region. ... CDI More Info
CDI-supported Research Links Gut Microbes to Deadly Intestinal Disease in Preemies An imbalance of certain gut microbes appears to be the underlying cause of a frequently fatal intestinal illness in premature babies, according to research partly funded by the Children's Discovery Institute.... CDI More Info