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Research Highlights
Seeking a Fighting Chance for Cystic Fibrosis Patients

When you have two great passions — children and science — going to medical school and becoming a pediatrician seem like obvious choices. But, choosing a pediatric specialty proved more challenging for Jessica Pittman, MD, MPH, pediatrics, until she met Dylan. ...Learn More

New Research on Pediatric Brain Tumors Underway

According to Dr. Rubin, MD, PhD, pediatrics, despite decades of research, we still have little understanding of the fundamental mechanisms that drive the genesis of pediatric brain tumors and the requirements for effective treatment. Now, the discovery of a key player in making brain tumors resistant to treatment by Washington University School of Medicine’s Albert Kim, MD, PhD, neurosurgery, will inform a CDI study that brings Dr. Kim together with Dr. Rubin, developmental biologist Kristen Kroll, PhD, and Hiroko Yano, PhD, an expert in neuro-epigenetics, as co-principal investigators to crack the code of what happens during brain stem cell differentiation that sets a child on the path to developing this malignant brain tumor. ...Learn More

Moving Toward Personalized Medicine

Learn how a little boy helped researchers gain a greater understanding of our immune system....Learn More

Healing a Broken Heart

Can we put immune cells to work to reverse pediatric cardiomyopathy? One CDI researcher intends to find out....Learn More

In Defense of the Peanut

A New CDI study seeks to uncover the early environmental exposures that put children at risk for food allergies....Learn More

News & Events
Gordon Recognized for Leading Research on Microbiome Public research, development and manufacturing company Agilent Technologies has recognized CDI Board Member and prominent researcher Jeffrey I. Gordon, MD, with a Thought Leader Award. The award supports his research into the role of the gut microbiome in human health. Dr. Gordon's work has begun to uncover the complex relationship between the tens of trillions of microbes that live in the gastrointestinal tract, our health status and our disease risks. ... CDI More Info
The CDI Welcomes New Executive Director Gary A. Silverman, MD, PhD, a national leader in newborn medicine, has been named the Harriet B. Spoehrer Professor and head of the Department of Pediatrics at Washington University School of Medicine in St. Louis. With the new appointment, effective in April, Dr. Silverman will become pediatrician-in-chief at St. Louis Children’s Hospital and executive director of the Children’s Discovery Institute.... CDI More Info
CDI Researchers Now Part of Pediatric Neuro-Oncology Consortium When the Washington University School of Medicine joined the Pacific Pediatric Neuro-Oncology Consortium, it brought with it three CDI-funded physician-scientists who now have access to the most cutting-edge brain tumor therapies for the children of St. Louis and surrounding region. ... CDI More Info
CDI-supported Research Links Gut Microbes to Deadly Intestinal Disease in Preemies An imbalance of certain gut microbes appears to be the underlying cause of a frequently fatal intestinal illness in premature babies, according to research partly funded by the Children's Discovery Institute.... CDI More Info
Preemies’ Gut Bacteria Reveal Vast Scope of Antibiotic Resistance A new study by CDI collaborators Gautam Dantas, PhD, and Barbara Warner, MD, reveals extensive antibiotic resistance in the gut bacteria of premature infants. The researchers say these findings support the push to minimize routine use of antibiotics in these patients.... CDI More Info