Zebrafish Models for Pediatric Research


Zebrafish Models for Pediatric Research Services Cooperative (ZRSC) - a CDI funded Core

Micro-grant Request for Proposals

The current proposal submission period has ended.

Program Desription

Human genetic and genomic studies produce an avalanche of candidate human disease genes and specific mutations that require validation in vivo. To facilitate testing candidate pediatric disease genes, generation of new zebrafish pediatric disease models and piloting chemical screens, the Children’s Discovery Institute has funded a three-year proposal to establish a Zebrafish Models for Pediatric Research Cooperative of several WUSM core facilities, including: Fish Facility (FF), Genome Technology Access Center (GTAC), Genome Engineering and iPSC Core (GEiC), WU High Throughput Screening Core (HTS), Molecular Vectors Core (MVC), and WU Center for Cellular Imaging (WUCCI).

The CDI award will support the following types of projects:

  • Design and construction of guide RNAs and DNA constructs for gene disruption, editing and transgenesis
  • Generation, genotyping, maintenance and cryopreservation of zebrafish models
  • DNA sequencing and indel analysis
  • Gene expression and epigenetic profiling
  • Pilot chemical screens 

The Zebrafish Models for Pediatric Research Cooperative will enable new projects that utilize zebrafish to understand, diagnose, and develop treatments for birth defects and pediatric diseases.  The maximum grant amount is $10,000 per project.  An investigator may have only one project within the same year.  The number of awards made is dependent upon the number of qualifying applications received, and a minimum of 10 awards of up to $10,000 are anticipated to be funded in each FY17, FY18, and FY19.

To obtain approximate project costs and/or request additional information regarding your research project, contact the applicable core:  

FF Core, Isa Roszko, roszkoi@wustl.edu
GTAC Core, Richard Head, rhead@wustl.edu
GEiC Core, Xiaoxia Cui, x.cui@wustl.edu
HTSC, Maxine Ilagan, ilaganmg@wustl.edu
TVC, Renate Lewis, lewisr@wustl.edu
WUCCI Core, James Fitzpatrick, fitzp@wustl.edu

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