Funded Research

Role of Enterocyte Glut9 in Intestinal Urate Handling and Energy Homeostasis
Principal Investigator(s):
  • Brian DeBosch, M.D., Ph.D. Pediatrics
Status:
Completed
Center(s):
  • Center for Metabolism and Immunity
Award Mechanism:
Faculty Recruitment/Scholar Award
Project Period:
7/1/2014 - 6/30/2019
Total Amount:
$300,000

Dr. DeBosch will study the role of enterocytes, the cells lining the gastrointestinal tract, in metabolism and controlling levels of a metabolite called uric acid that may cause childhood pre-diabetes if not regulated properly. Initial pre-clinical studies will use mice either lacking or overexpressing an intestinal uric acid transporter called GLUT9. Dr. DeBosch received his MD and PhD from Washington University School of Medicine in 2008 and completed his pediatrics residency at St. Louis Children’s Hospital in 2010, followed by a clinical fellowship in pediatric gastroenterology at Washington University. As an NIH-funded Pediatric Scientist Development Program (PSDP) research fellow in the lab of Dr. Kelle Moley, he has been studying the role of glucose transporters called GLUT8 and GLUT9 in mammalian metabolic homeostasis and identified important links with pre-diabetes and metabolic syndrome. Dr. DeBosch has been very productive and has published 14 journal papers, 11 as first author. In addition to his PSDP award, he has received numerous other prestigious awards, including the Spencer T. and Ann W. Olin Medical Science Fellowship—the highest award for a graduate thesis at Washington University. Dr. DeBosch is an instructor of pediatrics at Washington University.

Potential impact: This research could lead to novel therapeutic measures or lifestyle interventions to treat or prevent Type 2 diabetes and pre-diabetes in children.