Funded Research

Cellular Imaging and Correlated Microscopy Tools to Study Pathogenesis of Pediatric Diseases
Principal Investigator(s):
  • James Fitzpatrick, Ph.D. Neuroscience
  • All Centers
Award Mechanism:
Core Large Initiative
Project Period:
7/1/2019 - 6/30/2022
Total Amount:

Microscopy has evolved from a disparate set of imaging techniques into a suite of tools for studying pathogenesis and developing treatments for pediatric disease. Equipment cost coupled with required technical knowledge has generated a fundamental gap between availability of modern imaging approaches, and their access to investigators. The Washington University Center for Cellular Imaging (WUCCI) was created to address this issue, and presents a new paradigm for a shared resource, providing education, service, technology development and collaborative opportunities.

The WUCCI offers a wide array of technology, spanning light (confocal, light sheet, multiphoton, and super resolution) microscopy, as well as ultrastructural modalities, including scanning and transmission electron microscopy and cryo-electron microscopy. Support, education, and service by the WUCCI staff provides researchers with a platform to explore morphological and dynamic biological processes at multiple levels, relevant to investigators at all four CDI centers.

   Financial and technical support for CDI projects and pilot data through a micro-grant program.

·            Training on all instrument platforms, consultation on experimental design, and support for digital                              image processing and analysis.

The WUCCI will enhance a broad array of existing and future projects in which cellular imaging is used to provide a new understanding of childhood diseases studied in all CDI centers.

Washington University Center for Cellular Imaging