CDI Funding Helps Propel Cancer Immunotherapy

John DiPersio, MD, PhD, (right) leads CDI-funded team developing an "off-the-shelf" CAR-T immunotherapy for hard-to-treat T cell cancers. The study evaluates the approach in mice with human T cell acute lymphoblastic leukemia....Learn More

Genetic Lung Disease's Molecular Roots Identified

Using cells from children diagnosed with primary ciliary dyskinesia, a genetic lung disease, CDI-funded physician-scientists have figured out how mutations disrupt the clearing of the airways. ...Learn More

Early-Stage Pediatric Investigators Continue to Need Support

Supporting the Children's Discovery Institute is one way philanthropy can correct disparities in funding. ...Learn More

A Bold New Way of Understanding the Anatomy of the Heart

The story of this Children’s Discovery Institute-funded grant started with a phone call. Washington University School of Medicine biomedical engineer Jon Silva, PhD, was at a Microsoft conference and had just seen a demonstration of the Microsoft Hololens, the first self-contained hologram computer. This technology enables its user, who is looking through specially designed goggles, to interact and engage with three-dimensional holograms in their three-dimensional space. They call it augmented reality....Learn More

Two Experts. One Protein. And the Mission That Binds Them

A CDI resaerch team has embarked on a drug discovery journey that may lead to new treatment for pediatric nonalcoholic fatty liver disease (NFLD. This serious condition is a troubling consequence of the rise in childhood obesity that can lead to diminished liver function later in life. According to the Centers for Disease Control and Prevention, one in five school-aged children (ages 6-19) is obese. ...Learn More