Comprehensive Respiratory Virus Discovery and Detection in Pediatric Transplant Patients

Principal Investigator(s):

David Wang, Ph.D. - Molecular Microbiology

Status: Completed

Center(s): Center for Pediatric Pulmonary Disease

Award Mechanism: Interdisciplinary Research Initiative

Project Period: 2/1/2009 - 1/31/2013

Total Amount: $300,000

Collaborators: Charles Canter, Shalini Shenoy, Paul Hmiel, Yumirle Turmelle

Project Summary:
Infections in transplant recipients are the leading cause of death after transplantation and respiratory infections contribute significantly to both fatal and non-fatal cases. Efforts to reduce the respiratory disease burden in pediatric transplant patients require, first of all, understanding which microbes cause disease. In most previous studies, no infectious agent can be identified in ~30% of all cases of respiratory infection. Some of these are likely to be caused by unknown viruses that have never been described before. The goal of this project is to use state-of-the-art technologies to systematically identify the viruses, both known and new, present in cases of acute respiratory infection in transplant patients. With this information, it will be possible to develop new drug treatments or vaccines to minimize the impact of respiratory infections on the highly immunocompromised transplant recipients.