Airway Epithelial Cell Core

Principal Investigator(s):

Steven L. Brody, M.D. - Medicine

Status: Completed

Center(s): Center for Pediatric Pulmonary Disease

Award Mechanism: Core Large Initiative

Project Period: 4/15/2007 - 4/14/2012

Total Amount: $350,000

Collaborators: Michael J. Holtzman, G. Alexander Patterson

Project Summary:
Primary culture of airway epithelial cells is a valuable model for the study of lung disease and has been crucial for understanding the biology and therapy of many childhood diseases including asthma, respiratory virus infection, and cystic fibrosis, a major genetic lung disease of children. This Core Resource provides primary culture airway epithelial cell preparations from human and mouse for use by investigators studying basic epithelial cell lung biology and therapeutic strategies for lung diseases in children. Cells in these cultures are differentiated into ciliated and secretory types, to provide a powerful model that is vital for research in a wide variety of childhood lung diseases. The Core also has a tissue repository of normal and diseased lung epithelial cells, and provides consultation and training of investigators in culture methods, analysis and epithelial cell manipulation.