Treatment Strategy May Reduce Infants' Wheezing Caused by Virus


The antibiotic azithromycin may reduce the risk of recurrent wheezing in infants hospitalized with a common respiratory infection, according to a small pilot study at Washington University School of Medicine, partly funded by the CDI...More

March of Dimes Chooses WUSM for Third Prematurity Reseach Center


The March of Dimes joined with Washington University in St. Louis to launch the third Prematurity Research Center aimed exclusively at finding the unknown causes of preterm birth....More

CDI Announces New Core Pilot Grant Program


The CDI has recently established a Human Pluripotent Stem Cell Core (hPSC) to advance research in human disease and regenerative medicine. ...More

Season Two of Hospital Docu-series to Follow Two CDI Researchers


CDI Investigators Jeff Bednarski, MD, PhD, pediatrics; and Todd Druley, MD, PhD, pediatrics, will be featured in season two of The Frontline for Hope, a six-part docu-series set to air starting Saturday, November 22, at 6:30 p.m. on KSDK, NewsChannel 5....More

CDI Researcher Elected to Institute of Medicine


The National Academy of Sciences recently gave one of its highest honors to Kelle H. Moley, MD, a principle investigator at the CDI-funded Women and Infants Health Specimen Consortium....More

CDI Scientific Director Takes American Society of Hematology Post


Mary C. Dinauer, MD, PhD, the scientific director of the Children’s Discovery Institute was elected to the Executive Committee of the American Society of Hematology. ...More

CDI Researcher Turns Attention to Ebola and Makes Important Discovery


CDI researcher Dr. Gaya Amarasinghe and his colleagues recently made an important discovery that pinpoints one way the Ebola virus evades the body's antiviral defenses. This important insight could lead to new therapies for the virus, in the midst of its biggest outbreak on record in Western Africa....More

New Culprit for Metabolic Syndrome Identified


Excess uric acid, a normal waste product removed by the body through the kidneys and intestines, may play a direct causative role in metabolic syndrome. A study by Brian J. DeBosch, MD, PhD, pediatrics, who was recently funded by the CDI for other research, shows that the gut is an important clearance mechanism for uric acid, opening the door to potential new therapies for preventing or treating type 2 diabetes and metabolic syndrome....More

A Model of Persistence


Christina Stallings, PhD, is using her CDI grant to combat serious lung infections....More

Newborn Infant Guts Hold Key to Long-term Health


Foundational funding from the Children's Discovery Institute led to another important insight into how bacterial communities develop in the newborn gut. ...More

One Route to Malaria Drug Resistance Found


CDI investigator Audrey Odom, MD, PhD, and her colleagues at Washington University School of Medicine, have found one way the malaria parasite becomes resistant to fosmidomycin, an antimalarial drug in clinical trials. ...More

Pedal the Cause for Pediatric Cancer Research


Private support for pediatric cancer research has never been more critical. And, you can make a difference....More

Severe Scoliosis Linked to Rare Mutations


CDI-funded researcher Christina A. Gurnett, MD, PhD, has found genetic mutations that may be helpful in predicting severe scoliosis. ...More

A Tale of Two Leukemias


Two stories of struggle and survival, two CDI researchers looking for answers....More

Soil Bacteria May Provide Clues to Curbing Antibiotic Resistance


“Soil bacteria have strategies for fighting antibiotics that we’re only just starting to learn about,” says CDI-funded researcher, Gautam Dantas, PhD, assistant professor of pathology and immunology at Washington University School of Medicine. ...More

Study of Rare Disorder Sheds Light on Common Conditions


A CDI faculty scholar identifies genetic factors that increase the risk for vascular problems in patients with Williams syndrome, paving the way for better diagnostics and treatments for a range of diseases....More

Gut Bacteria Can Cause Life-threatening Infections in Pre-term Babies


The CDI provides key funding for laboratory infrastructure supporting important research, such as the recently published study led by Phillip I. Tarr, MD, and Barbara B. Warner, MD. ...More

Infants With Leukemia Inherit Susceptibility


CDI-funded research, presented at the 2013 CDI Investor Symposium and recently published in the online journal Leukemia, indicates that babies with leukemia have inherited a genetic predisposition that makes them highly susceptible to the disease. ...More

CDI Hosts First Visiting Investigator


In the spirit of its collaborative vision, the Children’s Discovery Institute sponsored its first visiting researcher in January: David Ingram, MD, the Hugh McK Landon Professor of Pediatrics and of Biochemistry and Molecular Biology, director of the Section of Neonatal-Perinatal Medicine at Indiana University School of Medicine....More

CDI Awards $3.1 Million in New Pediatric Research Grants


Washington University School of Medicine researchers in pediatric lung disease, childhood cancer, malaria and short bowel syndrome will share $3.1 million in new research grants from the Children’s Discovery Institute (CDI). A total of 10 new studies, selected by the CDI’s scientific advisory board, will begin in February. ...More