Two Experts. One Protein. And the Mission That Binds Them
A CDI resaerch team has embarked on a drug discovery journey that may lead to new treatment for pediatric nonalcoholic fatty liver disease (NFLD. This serious condition is a troubling consequence of the rise in childhood obesity that can lead to diminished liver function later in life. According to the Centers for Disease Control and Prevention, one in five school-aged children (ages 6-19) is obese.
Antibiotic Resistance Hot Spots Identified
CDI investigator Gautam Dantas, PhD, led a study that surveyed ecosystems of bacteria and their capacity to resist antibiotics in low resource communities and identified areas ripe for bacteria to shuffle and share their resistance genes....More
Gordon Recognized for Leading Research on Microbiome
Public research, development and manufacturing company Agilent Technologies has recognized CDI Board Member and prominent researcher Jeffrey I. Gordon, MD, with a Thought Leader Award. The award supports his research into the role of the gut microbiome in human health. Dr. Gordon's work has begun to uncover the complex relationship between the tens of trillions of microbes that live in the gastrointestinal tract, our health status and our disease risks.
Preemies’ Gut Bacteria Reveal Vast Scope of Antibiotic Resistance
A new study by CDI collaborators Gautam Dantas, PhD, and Barbara Warner, MD, reveals extensive antibiotic resistance in the gut bacteria of premature infants. The researchers say these findings support the push to minimize routine use of antibiotics in these patients....More
Natural Sugar May Treat Fatty Liver Disease
Studying mice, pediatric gastroenterologist Brian DeBosch, MD, PhD, and his CDI-funded research team, has shown that a natural sugar called trehalose prevents the sugar fructose — thought to be a major contributor to nonalcoholic fatty liver disease — from entering the liver and triggers a cellular housekeeping process that cleans up excess fat buildup inside liver cells.
The research appeared Feb. 23 in the journal Science Signaling.
Reversing Effects of Childhood Malnutrition
Manipulating the makeup of microbes in the gut has the potential to provide new ways to treat and ultimately help prevent malnutrition. A CDI board of managers member made the discovery, now published in Science and Cell....More