Mechanism for SHOX Proteins to Regulate Skeletal Growth
- Center for Metabolism and Immunity
Interdisciplinary Research Initiative
2/1/2008 - 1/31/2011
Mutations in transcription factors that control specific gene expression patterns in bone morphogenesis lead to congenital skeletal dysplasias. Dr. Long is a recognized expert in this area, who with basic science and clinical collaborators, will define the pathways from loss of a transcription factor to abnormal bone cell development and investigate these pathways in children with congenital skeletal dysplasia. These studies have the potential to identify new therapeutic targets along this pathway that could be manipulated to regenerate limb growth in affected children with musculoskeletal defects.