Funded Research

Elucidating the Role of KLF7 in T Cell Development
Principal Investigator(s):
  • Laura Schuettpelz, M.D., Ph.D. Pediatrics
Status:
Completed
Center(s):
  • McDonnell Pediatric Cancer Center
Award Mechanism:
Faculty Recruitment/Scholar Award
Project Period:
7/1/2013 - 6/30/2018
Total Amount:
$300,000

Dr. Schuettpelz will pursue studies on the biology of therapy-resistant pediatric acute lymphocytic leukemia (ALL) cells and on the regulation of bone marrow stem cell function during transplantation.  Following graduation from Creighton University, she received her PhD and MD from Northwestern University.  Her graduate work on gene regulation during development resulted in publications in Nature and in Developmental Cell. Dr. Schuettpelz did her residency in Pediatrics at St. Louis Children’s Hospital followed by a fellowship in Pediatric Hematology Oncology at Washington University School of Medicine, where she was a recipient of a prestigious NIH-funded Pediatric Scientist Development Program (PSDP) award, under the mentorship of Dr. Daniel Link.  Her studies resulted in high profile publications in Blood, the Journal of the American Medical Association, and other journals. Dr. Schuettpelz also recently received a Hyundai Hope Grant.  She will continue these studies as a new Assistant Professor in the Department of Pediatrics, focusing on mouse models as initial research tools prior to clinical translation.

Potential impact: Her proposed research will identify new pathways that regulate lymphocytes and enhance our understanding of T cell development, leukemogenesis and therapy-resistance to develop new approaches to treatment. Additional studies on hematopoietic stem cell function could lead to improved protocols for their transplantation.