Funded Research

The Impact of Hearing Impairment on Cognitive Function and Quality of Life in Pediatric Cancer Survivors
Principal Investigator(s):
  • Allison King, M.D., Ph.D. Pediatrics
  • McDonnell Pediatric Cancer Center
Award Mechanism:
Interdisciplinary Research Initiative
Project Period:
2/1/2019 - 1/31/2022
Total Amount:

Project Summary

Advances in childhood cancer treatments have improved survival but leave long-term side effects of therapy including hearing loss.  There are very limited data available on how hearing loss impacts their intellectual and emotional state.  We will examine childhood cancer survivors who have received ototoxic chemotherapy and compare hearing impaired and unaffected patients for difficulties in cognitive function, audibility, and quality of life. This data will characterize the magnitude of this problem and begin to identify strategies that will lead to interventions to improve the outcomes of these patients.

Specific aims

·         To examine the effect of ototoxic hearing loss on cognitive function in non-central nervous system pediatric cancer survivors.

·         To examine the effect of ototoxic hearing loss on quality of life in non-central nervous system tumor pediatric cancer survivors.

·         To compare the HEAR-QL results to generic QOL from the PROMIS tools.

Potential impact on child health

By improving our understanding of the impact of hearing loss on pediatric cancer survivors, we will develop strategies to improve their condition and support the survivors as they engage in their daily activities at a higher level.