Funded Research

The Brain Tumor Data Bank
Principal Investigator(s):
  • Jeffrey R. Leonard, M.D. Neurosurgery
  • Joshua B. Rubin, M.D., Ph.D. Pediatrics Visit Website
Status:
Completed
Center(s):
  • McDonnell Pediatric Cancer Center
Award Mechanism:
Core Large Initiative
Project Period:
7/1/2009 - 6/30/2013
Total Amount:
$700,000
Survival from malignant pediatric brain tumors has not dramatically improved over the past 15 years. Among the major obstacles to the advancement of care is the inability to successfully model native brain tumor biology in the laboratory. This initiative overcomes this limitation in pediatric brain tumor research by creating a highly correlated bank of material and data that will provide: 1) native brain tumor tissue for genomic and proteomic analyses; 2) primary tumor cultures for genome wide RNA interference studies of tumor biology, and robotic screening of small molecule libraries for novel drug activities; and 3) primary intracranial xenografts for preclinical evaluations of novel drugs. All of this material will be banked and extensively annotated with clinical information on an ongoing basis. The tissue and all other resources derived from the facility are available to investigators at Washington University interested in research relevant to pediatric brain tumors. Initial studies included establishing primary tumor growth as xenografts in the brains of mice and using this material to examine the effect of individual genes on tumor growth through expression of lentiviral encoded interfering RNA with the RNAi library core (see Sheila Stewart) developed with Children’s Discovery Institute funding.