Funded Research

Modulating the Intestinal Immune Response in the Pathogenesis of Necrotizing Enterocolitis
Principal Investigator(s):
Status:
Active
Center(s):
  • Center for Metabolism and Immunity
Award Mechanism:
Faculty Recruitment/Scholar Award
Project Period:
2/1/2017 - 1/31/2022
Total Amount:
$300,000

Brief background of the proposal and its relevance to the CDI’s objectives

Dr. Good is a Neonatologist who studies the devastating gastrointestinal disease necrotizing enterocolitis (NEC). NEC affects up to 10% of premature infants and is characterized by an uncontrolled inflammatory response in the intestine. The goals of the proposed research are to further characterize the inflammatory signaling pathways involved in NEC and to investigate how these responses can be modified or prevented through dietary modifications.

Specifically, we are interested in the following:

•      Determining the components of breast milk that are protective against NEC.

•      Understanding the signaling pathways that are involved in NEC development.

•      Predicting the infants at risk for NEC.

Potential impact on child health

Necrotizing enterocolitis is a leading cause of death in premature babies. The overarching goal of her laboratory is to precisely identify those babies at highest risk for NEC and to develop novel preventative strategies to protect these fragile babies from this devastating disease.