New Clues Found to Common Respiratory Virus
Researchers funded by the CDI to study a common virus striking children, respiratory syncytial virus (RSV), have found clues to how it causes disease. They mapped the molecular structure of an RSV protein that interferes with the body’s ability to fight off the virus. Knowing the structure of the protein will help them understand how the virus impedes the immune response, potentially leading to a vaccine or treatment for this common infection. ...More
New Translational Research Underway
The Children’s Discovery Institute board of managers recently approved more than $3.7 Million in new grant funding for 13 wide-ranging pediatric research studies, four of which take aim at childhood cancers, including two clinical trials. In four other studies, researchers will tackle serious disorders of the gastrointestinal tract in children, including a life-threatening condition call necrotizing enterocolitis (NEC) that develops in in some babies born prematurely. Funding also was awarded to two studies investigating different aspects of pediatric heart disease, as well as one designed to learn more about the long-term effects the Zika virus has on an infant’s brain.
Just Add Water: Artificial Blood to the Rescue
A study partly funded by the CDI brings the promise of artificial blood development closer to reality. Erythromer, a novel bood substitute developed by Washington University School of Medicine's Allan Doctor, MD, pediatrics, in collaboration with colleagues at the University of Illinois at Urbana Champaign, has been shown to emulate vital functions of natural red blood cells....More
Protecting Childhood with Precision Medicine
See how CDI supporters have put in motion a precision medicine revolution that will continue to spark innovation and deepen our understanding of the origins of pediatric disease for decades to come....More
Gordon Receives Beering Award
CDI board of managers member,Jeffrey I. Gordon, MD, has been honored with the Steven C. Beering Award for his seminal contributions to establishing the field of human microbiome research. ...More
New CDI Studies Underway
The Children’s Discovery Institute recently allocated $2.8 million toward comprehensive genome analysis to improve the ability to diagnosis birth defects, toward work that will seek to identify biomarkers of cognitive dysfunction in survivors of pediatric brain tumors and more....More
Riding for Vivian
Vivian Keith is a feisty, sometimes stubborn 3-year-old with curly-cue hair and a twin brother named Lane. Her mom, Ginger, always knew Vivian was a determined little girl but she didn’t realize the depth of that determination until Vivian had to battle cancer....More
Antibiotic Resistance Hot Spots Identified
CDI investigator Gautam Dantas, PhD, led a study that surveyed ecosystems of bacteria and their capacity to resist antibiotics in low resource communities and identified areas ripe for bacteria to shuffle and share their resistance genes....More
The CDI Welcomes New Executive Director
Gary A. Silverman, MD, PhD, a national leader in newborn medicine, has been named the Harriet B. Spoehrer Professor and head of the Department of Pediatrics at Washington University School of Medicine in St. Louis. With the new appointment, effective in April, Dr. Silverman will become pediatrician-in-chief at St. Louis Children’s Hospital and executive director of the Children’s Discovery Institute....More
CDI Researchers Now Part of Pediatric Neuro-Oncology Consortium
When the Washington University School of Medicine joined the Pacific Pediatric Neuro-Oncology Consortium, it brought with it three CDI-funded physician-scientists who now have access to the most cutting-edge brain tumor therapies for the children of St. Louis and surrounding region. ...More
Preemies’ Gut Bacteria Reveal Vast Scope of Antibiotic Resistance
A new study by CDI collaborators Gautam Dantas, PhD, and Barbara Warner, MD, reveals extensive antibiotic resistance in the gut bacteria of premature infants. The researchers say these findings support the push to minimize routine use of antibiotics in these patients....More
Dietary Link to Stunted Growth Identified
A team of researchers led by senior author and Children's Discovery Institute (CDI)-funded researcher Mark J. Manary, MD, at Washington University School of Medicine in St. Louis, has found that inadequate dietary intake of essential amino acids and the nutrient choline is linked to stunting. That knowledge may unlock the door to new approaches to treat the debilitating condition.
The findings are published online in EBioMedicine....More
Natural Sugar May Treat Fatty Liver Disease
Studying mice, pediatric gastroenterologist Brian DeBosch, MD, PhD, and his CDI-funded research team, has shown that a natural sugar called trehalose prevents the sugar fructose — thought to be a major contributor to nonalcoholic fatty liver disease — from entering the liver and triggers a cellular housekeeping process that cleans up excess fat buildup inside liver cells.
The research appeared Feb. 23 in the journal Science Signaling.
Reversing Effects of Childhood Malnutrition
Manipulating the makeup of microbes in the gut has the potential to provide new ways to treat and ultimately help prevent malnutrition. A CDI board of managers member made the discovery, now published in Science and Cell....More