News, Features and Publications

CDI Researcher's Work Earns $1 Million Funding from Hyundai


CDI researcher Todd Druley, MD, PhD, was awarded a $1 million Quantum Award from nonprofit Hyundai Hope on Wheels (HHOW) to continue his focus on acute myeloid leukemia (AML). ...More

CDI Investigator Named to Scientific Advisory Council of the Necrotizing Enterocolitis (NEC) Society


Misty Good, MD,assistant professor of pediatrics at Washington University School of Medicine in St. Louis, has been named to the Scientific Advisory Council of the Necrotizing Enterocolitis (NEC) Society. The nonprofit aims to reduce cases of NEC, a potentially fatal intestinal disease in premature newborns....More

Another Honor for CDI Leader and Founder of Gut Microbiome Research


CDI Board of Managers member and world-renowned scientist Jeffrey I. Gordon, MD, has received the Sanofi-Institut Pasteur International Award for his role in founding and leading the field of gut microbiome research....More

Antibiotics Warranted for Kids with Minor Staph Infections


A former CDI faculty scholar and her research team have found that prescribing antibiotics is warranted for children with minor staph infections. The drugs help to reduce the risk of recurrent infections....More

New Clues Found to Common Respiratory Virus


Researchers funded by the CDI to study a common virus striking children, respiratory syncytial virus (RSV), have found clues to how it causes disease. They mapped the molecular structure of an RSV protein that interferes with the body’s ability to fight off the virus. Knowing the structure of the protein will help them understand how the virus impedes the immune response, potentially leading to a vaccine or treatment for this common infection. ...More

New Translational Research Underway


The Children’s Discovery Institute board of managers recently approved more than $3.7 Million in new grant funding for 13 wide-ranging pediatric research studies, four of which take aim at childhood cancers, including two clinical trials. In four other studies, researchers will tackle serious disorders of the gastrointestinal tract in children, including a life-threatening condition call necrotizing enterocolitis (NEC) that develops in in some babies born prematurely. Funding also was awarded to two studies investigating different aspects of pediatric heart disease, as well as one designed to learn more about the long-term effects the Zika virus has on an infant’s brain. ...More

Just Add Water: Artificial Blood to the Rescue


A study partly funded by the CDI brings the promise of artificial blood development closer to reality. Erythromer, a novel bood substitute developed by Washington University School of Medicine's Allan Doctor, MD, pediatrics, in collaboration with colleagues at the University of Illinois at Urbana Champaign, has been shown to emulate vital functions of natural red blood cells....More

Protecting Childhood with Precision Medicine


See how CDI supporters have put in motion a precision medicine revolution that will continue to spark innovation and deepen our understanding of the origins of pediatric disease for decades to come....More

Gordon Receives Beering Award


CDI board of managers member,Jeffrey I. Gordon, MD, has been honored with the Steven C. Beering Award for his seminal contributions to establishing the field of human microbiome research. ...More

New CDI Studies Underway


The Children’s Discovery Institute recently allocated $2.8 million toward comprehensive genome analysis to improve the ability to diagnosis birth defects, toward work that will seek to identify biomarkers of cognitive dysfunction in survivors of pediatric brain tumors and more....More

CDI Researcher Receives Prestigious Award to Further Malaria Research


Audrey R. Odom, MD, PhD, a noted CDI-funded malaria researcher at Washington University School of Medicine in St. Louis, has received a five-year, $500,000 award from the Burroughs Wellcome Fund to further her research into the parasitic disease. ...More

Riding for Vivian


Vivian Keith is a feisty, sometimes stubborn 3-year-old with curly-cue hair and a twin brother named Lane. Her mom, Ginger, always knew Vivian was a determined little girl but she didn’t realize the depth of that determination until Vivian had to battle cancer....More

Development of Gut Microbes and Gut Immunity Linked


CDI-funded research studying twins from birth to age 2 has shown that the gut’s immune system develops in sync with the gut’s tens of trillions of microbes....More

Antibiotic Resistance Hot Spots Identified


CDI investigator Gautam Dantas, PhD, led a study that surveyed ecosystems of bacteria and their capacity to resist antibiotics in low resource communities and identified areas ripe for bacteria to shuffle and share their resistance genes....More

The CDI Welcomes New Executive Director


Gary A. Silverman, MD, PhD, a national leader in newborn medicine, has been named the Harriet B. Spoehrer Professor and head of the Department of Pediatrics at Washington University School of Medicine in St. Louis. With the new appointment, effective in April, Dr. Silverman will become pediatrician-in-chief at St. Louis Children’s Hospital and executive director of the Children’s Discovery Institute....More

CDI Researchers Now Part of Pediatric Neuro-Oncology Consortium


When the Washington University School of Medicine joined the Pacific Pediatric Neuro-Oncology Consortium, it brought with it three CDI-funded physician-scientists who now have access to the most cutting-edge brain tumor therapies for the children of St. Louis and surrounding region. ...More

CDI-supported Research Links Gut Microbes to Deadly Intestinal Disease in Preemies


An imbalance of certain gut microbes appears to be the underlying cause of a frequently fatal intestinal illness in premature babies, according to research partly funded by the Children's Discovery Institute....More

Preemies’ Gut Bacteria Reveal Vast Scope of Antibiotic Resistance


A new study by CDI collaborators Gautam Dantas, PhD, and Barbara Warner, MD, reveals extensive antibiotic resistance in the gut bacteria of premature infants. The researchers say these findings support the push to minimize routine use of antibiotics in these patients....More

Dietary Link to Stunted Growth Identified


A team of researchers led by senior author and Children's Discovery Institute (CDI)-funded researcher Mark J. Manary, MD, at Washington University School of Medicine in St. Louis, has found that inadequate dietary intake of essential amino acids and the nutrient choline is linked to stunting. That knowledge may unlock the door to new approaches to treat the debilitating condition. The findings are published online in EBioMedicine....More

Natural Sugar May Treat Fatty Liver Disease


Studying mice, pediatric gastroenterologist Brian DeBosch, MD, PhD, and his CDI-funded research team, has shown that a natural sugar called trehalose prevents the sugar fructose — thought to be a major contributor to nonalcoholic fatty liver disease — from entering the liver and triggers a cellular housekeeping process that cleans up excess fat buildup inside liver cells. The research appeared Feb. 23 in the journal Science Signaling. ...More

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