2017 Articles and Releases

CDI Researcher's Work Earns $1 Million Funding from Hyundai

CDI researcher Todd Druley, MD, PhD, was awarded a $1 million Quantum Award from nonprofit Hyundai Hope on Wheels (HHOW) to continue his focus on acute myeloid leukemia (AML). ...More

CDI Funding Helps Propel Cancer Immunotherapy

John DiPersio, MD, PhD, (right) leads CDI-funded team developing an "off-the-shelf" CAR-T immunotherapy for hard-to-treat T cell cancers. The study evaluates the approach in mice with human T cell acute lymphoblastic leukemia....More

Genetic Lung Disease's Molecular Roots Identified

Using cells from children diagnosed with primary ciliary dyskinesia, a genetic lung disease, CDI-funded physician-scientists have figured out how mutations disrupt the clearing of the airways. ...More

Early-Stage Pediatric Investigators Continue to Need Support

Supporting the Children's Discovery Institute is one way philanthropy can correct disparities in funding. ...More

CDI Investigator Named to Scientific Advisory Council of the Necrotizing Enterocolitis (NEC) Society

Misty Good, MD,assistant professor of pediatrics at Washington University School of Medicine in St. Louis, has been named to the Scientific Advisory Council of the Necrotizing Enterocolitis (NEC) Society. The nonprofit aims to reduce cases of NEC, a potentially fatal intestinal disease in premature newborns....More

A Bold New Way of Understanding the Anatomy of the Heart

The story of this Children’s Discovery Institute-funded grant started with a phone call. Washington University School of Medicine biomedical engineer Jon Silva, PhD, was at a Microsoft conference and had just seen a demonstration of the Microsoft Hololens, the first self-contained hologram computer. This technology enables its user, who is looking through specially designed goggles, to interact and engage with three-dimensional holograms in their three-dimensional space. They call it augmented reality....More

Another Honor for CDI Leader and Founder of Gut Microbiome Research

CDI Board of Managers member and world-renowned scientist Jeffrey I. Gordon, MD, has received the Sanofi-Institut Pasteur International Award for his role in founding and leading the field of gut microbiome research....More

Antibiotics Warranted for Kids with Minor Staph Infections

A former CDI faculty scholar and her research team have found that prescribing antibiotics is warranted for children with minor staph infections. The drugs help to reduce the risk of recurrent infections....More

Two Experts. One Protein. And the Mission That Binds Them

A CDI resaerch team has embarked on a drug discovery journey that may lead to new treatment for pediatric nonalcoholic fatty liver disease (NFLD. This serious condition is a troubling consequence of the rise in childhood obesity that can lead to diminished liver function later in life. According to the Centers for Disease Control and Prevention, one in five school-aged children (ages 6-19) is obese. ...More

Molecules to Missiles

CDI funding tests the promise of nanomedicine in brain tumor treatment....More

Works at Work to Find the Origins of Disease

When it comes to childhood diseases, lysosome storage diseases probably aren’t top of mind to most people, but, Abhinav Diwan, MD, medicine, would argue that they should be. ...More

Announcing Exciting New Funding

The CDI recently completed its spring funding cycle with awards for two promising projects. One project takes aim at T-cell acute lymphoblastic leukemia (T-ALL), a class of devastating cancers with high rates of relapse and loss of life in both children and adults. The other supports a new CDI faculty scholar interested in the underlying mechanisms of impaired fetal brain development in children with congenital heart defects....More

New Clues Found to Common Respiratory Virus

Researchers funded by the CDI to study a common virus striking children, respiratory syncytial virus (RSV), have found clues to how it causes disease. They mapped the molecular structure of an RSV protein that interferes with the body’s ability to fight off the virus. Knowing the structure of the protein will help them understand how the virus impedes the immune response, potentially leading to a vaccine or treatment for this common infection. ...More

Immune System: The Body's New Super Hero?

The journal Science Translational Medicine recently published a study showing promise for immunotherapy in treating recurrent acute myeloid leukemia (AML) in adults. The study’s lead author Rizwan Romee, MD, and senior author Todd Fehniger, MD, PhD, from the division of oncology of Washington University School of Medicine, barely let the ink dry before they were on to their next challenge. In collaboration with Jeffrey Bednarski, MD, PhD, pediatrics, they submitted a proposal to and received funding from the Children’s Discovery Institute to pursue the same study in children....More

Dale Cammon

Dale Cammon’s involvement with St. Louis Children’s Hospital and the Children’s Discovery Institute (CDI) runs long and deep....More

Investigating NEC

In the last issue of CDI Pathways, we told you about the newly funded research your support helped make possible. Now, I would like to focus on five of those studies. Each investigates necrotizing enterocolitis (NEC), which is a devastating disease that can threaten the lives of our most vulnerable babies. ...More

CDI Leaders Identify Surprising Culprit in Nerve Cell Damage

In new research, scientists at Washington University School of Medicine who play important leadership roles in the Children's Discovery Institute uncovered findings that suggest ways to block nerve cell damage in neurodegenerative diseases....More

New Translational Research Underway

The Children’s Discovery Institute board of managers recently approved more than $3.7 Million in new grant funding for 13 wide-ranging pediatric research studies, four of which take aim at childhood cancers, including two clinical trials. In four other studies, researchers will tackle serious disorders of the gastrointestinal tract in children, including a life-threatening condition call necrotizing enterocolitis (NEC) that develops in in some babies born prematurely. Funding also was awarded to two studies investigating different aspects of pediatric heart disease, as well as one designed to learn more about the long-term effects the Zika virus has on an infant’s brain. ...More

Audrey Odom John: At the Global Forefront of Ending Malaria

See where a 2009 Faculty Scholar Award helped take this CDI researcher. ...More

Just Add Water: Artificial Blood to the Rescue

A study partly funded by the CDI brings the promise of artificial blood development closer to reality. Erythromer, a novel bood substitute developed by Washington University School of Medicine's Allan Doctor, MD, pediatrics, in collaboration with colleagues at the University of Illinois at Urbana Champaign, has been shown to emulate vital functions of natural red blood cells....More

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